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ECOG-ACRIN E2211 trial

Oncologyme  /  Mar 26, 2023

In phase II ECOG-ACRIN E2211 trial, the addition of Capecitabine to Temozolomide significantly improved the progression-free survival (PFS) in patients with advanced, low or intermediate grade pancreatic #Neuroendocrine_Tumors (NETs). In the interim analysis, median PFS was 22.7 months in the capecitabine/temozolomide group vs 14.4 months in the temozolomide group (HR = 0.58, P = .022). In the final analysis, median OS was 53.8 months for temozolomide and 58.7 months for capecitabine/temozolomide (HR = 0.82, p = 0.42).