In a large Propensity score matched retrospective study was conducted to assess the value of systemic Therapy and radiation therapy in Stage I Nodal Marginal Zone Lymphoma (#NMZL). The study which was published in Practical radiation oncology, included 1562 patients, from which (49%) received no treatment, 721 (23%) received ST alone, 799 (25%) received RT alone, and 119 (4%) received both ST and RT.

Results showed that Radiation therapy improved OS compared with no Radiation therapy, and Systemic Therapy was not a factor associated with OS. A radiation oncologist should be consulted for all patients with stage I NMZL for multidisciplinary decision making.