Although #colonoscopy is widely used as a #screening test to detect colorectal cancer (#CRC), it is more invasive and resources consuming than FOB in stool and sigmoidoscopy, so a randomized, pragmatic trial was conducted by the NordICC Study Group to determine its actual benefits. In this study, healthy men and women 55 to 64 years of age were randomly assigned in a 1:2 ratio either to receive an invitation to undergo a single screening colonoscopy (the invited group) or to receive no invitation or screening (the usual-care group)

Results showed that the risk of colorectal cancer at 10 years was lower among participants who were invited to undergo screening colonoscopy than among those who were assigned to no screening (0.98% in the invited group and 1.20% in the usual-care group), a risk reduction of 18% (risk ratio, 0.82; 95% confidence interval [CI], 0.70 to 0.93). The number needed to invite to undergo screening to prevent one case of colorectal cancer was 455 (95% CI, 270 to 1429).